Japanese Journal of Medicine
Online ISSN : 1881-123X
Print ISSN : 0021-5120
A Case of HTLV-I-associated Myelopathy with IgA Nephropathy and Pseudohypoparathyroidism Type 1
Yoshihiro YOSHIDASatoshi TAKENAGAShigetsugu NOGUCHIKen SONODAYumiko ARIMURAKiyoshige NIINAYuichiro YASUMOTOMitsuhiro OSAME
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1991 Volume 30 Issue 6 Pages 582-587


We report a case of HAM/TSP presenting with short stature, mental retardation, skin eruptions, uterine and ovarian hypogenesis and nephropathy. Skin erythema was noted since from the age of three years old and spasticity of lower extremities from elementary school age. Serum calcium level showed 4.1 mEq/l. Recombinant human PTH infusion resulted in no response of phosphate excretion. The persistent proteinuria prompted renal needle biopsy, which revealed IgA and C1q deposits in glomerular mesangium. A diagnosis of pseudohypoparathyroidism and IgA nephropathy was entertained. This patient with pseudohypoparathyroidism who has a deficient immune system was seized with the early onset of HAM/TSP and IgA nephropathy.

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