A Candidate Case for Lymphocytic Infundibulo-Neurohypophysitis Mimicking a Neurohypophysial Tumor

Satoru TSUJII; Juji TAKEUCHI; Makoto KOH; Masatoshi MIZUTA; Yoshie AZUMA; Mariko OISHI; Yoshiharu AKAZAWA; Hideshi KUZUYA

doi:10.2169/internalmedicine.36.293

Satoru TSUJII, Juji TAKEUCHI, Makoto KOH, Masatoshi MIZUTA, Yoshie AZUMA, Mariko OISHI, Yoshiharu AKAZAWA, Hideshi KUZUYA

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Satoru TSUJII
The Division of Endocrine and Metabolic Diseases, Department of Clinical Research, Kyoto National Hospital
Juji TAKEUCHI
Division of Neurosurgery, Utano Sanatorium National Hospital
Makoto KOH
The Division of Endocrine and Metabolic Diseases, Department of Clinical Research, Kyoto National Hospital
Masatoshi MIZUTA
The Division of Endocrine and Metabolic Diseases, Department of Clinical Research, Kyoto National Hospital
Yoshie AZUMA
The Division of Endocrine and Metabolic Diseases, Department of Clinical Research, Kyoto National Hospital
Mariko OISHI
The Division of Endocrine and Metabolic Diseases, Department of Clinical Research, Kyoto National Hospital
Yoshiharu AKAZAWA
The Division of Endocrine and Metabolic Diseases, Department of Clinical Research, Kyoto National Hospital
Hideshi KUZUYA
The Division of Endocrine and Metabolic Diseases, Department of Clinical Research, Kyoto National Hospital

Keywords: diabetes insipidus, magnetic resonance imaging (MRI), neurohypophysis, transsphenoidal surgery

JOURNAL FREE ACCESS

1997 Volume 36 Issue 4 Pages 293-297

DOI https://doi.org/10.2169/internalmedicine.36.293

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Abstract

A 56-year-old Japanese man presented with a 2-month duration of polyuria and polydipsia. The diagnosis of diabetes insipidus was confirmed by water deprivation and vasopressin injection. The secretory function of the adenohypophysis was estimated as normal by a variety of provocative tests. Magnetic resonance imaging (MRI) displayed the loss of the hyperintense signal of the neurohypophysis and a tumor-like lesion confined to the neurohypophysis. The tissue specimen resected at transsphenoidal surgery showed diffuse lymphocytic infiltration. These findings suggest that this is a candidate case for lymphocytic infundibuloneurohypophysitis (LIN) that is not identical to classical lymphocytic hypophysitis. This patient will be followed up to determine whether this case simply represents an early stage of classical hypophysitis or a different clinical entity.
(Internal Medicine 36: 293-297, 1997)

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