IPSJ Transactions on Bioinformatics
Online ISSN : 1882-6679
ISSN-L : 1882-6679
Improvement and Evaluation of a Mathematical Model for Fertilization Calcium Waves in Caenorhabditis Elegans
Momoko ImakuboJun TakayamaShuichi Onami
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2018 Volume 11 Pages 24-30

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Abstract

Ca2+ waves propagate through the oocyte during fertilization, activate the oocyte and induce embryonic development. Ca2+-induced Ca2+-release (CICR) is a mechanism of Ca2+ wave formation. We previously quantified the Ca2+ waves in the nematode Caenorhabditis elegans by using high-speed imaging and image analysis. We found that the waves consist of a rapid local rise at the point of sperm entry and a slow global wave. We demonstrated that the Nagumo model, which models the CICR by a reaction-diffusion equation, can produce a similar biphasic waveform. However, the model cannot represent the observed gradual decrease in maximum Ca2+ concentration with increasing distance from the point of sperm entry. In this study, we introduced a linear monotonically decreasing function into the reaction part of the Nagumo model. We demonstrated that our new model can produce the gradual decrease in maximum Ca2+ concentration with increasing distance from the point of sperm entry and a biphasic waveform simultaneously.

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© 2018 by the Information Processing Society of Japan
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