Intractable & Rare Diseases Research
Online ISSN : 2186-361X
Print ISSN : 2186-3644
ISSN-L : 2186-3644
Peripheral stimulation in treating Parkinson's disease: Is it a realistic idea or a romantic whimsicality?
Tetsuya AsakawaHuan FangZhen HongKenji SugiyamaTakao NozakiHiroki Namba
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2012 Volume 1 Issue 4 Pages 144-150


Parkinson's disease (PD) is a common, however, intractable neurodegenerative disorder in the aging population. Levodopa (L-dopa) administration is regarded as the most effective strategy in treating PD with prominent motor side-effects after undergoing long-term treatment. Surgical therapies such as deep brain stimulation (DBS) show certain efficacy, yet there are several limitations in adopting such surgical procedures. Therefore, performing electrical stimulation out of the brain, namely peripheral stimulation for PD has been a dream of many clinicians. Recently, the efficacy of dorsal column stimulation was verified in animal PD models; on the other hand, tons of acupunctural studies from East Asia claim good efficacy in treating PD both in bench and clinical studies. This review will introduce the progress of peripheral stimulation for PD, and will discuss the potential mechanisms involved in these strategies.

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© 2012 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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