Abstract
Many studies have been reported on the influence of adreno-cortical function in experimental tuberculosis, however, many problems remain. For instance, administration of a large quantity of adreno-cortical hormone seems to give bad results in tuberculosis. In the present study, the authors conducted experiments on adreno-cortical function in tuberculosis by hyper-and hypo-status of the adreno-cortical function.
Guinea pigs with negative tuberculin test were used. Fresh human-type tubercle bacilli of enough quantity, which shall eliminate any individual differences, were given intravenously and complete infection of tuberculosis were obtained. Then, cortisone, choline chloride, Vitamin-B3 and others, known as effective to adreno-cortical gland, were administered, and the survival period of the test animals and cholesterol in their adreno-cortical glands were examined.
Under the condition of cortisone's administration of large dose (over 0.1mg per day), period of survival was shortened and adreno-cortical cholesterol decreased, as in case of choline administration.
Administration of small quantity of cortisone (0.03mg per day) resulted in remarkably long period of survival and increase of adreno-cortical cholesterol. Under the condition of increase of quantity of adreno-cortical cholesterol, the survival period were lengthened.
