Abstract
This communication described briefly the neuropathological changes found in 13 postmortem cases with carbon monoxide poisoning including 2 cares of intermittent form and of brains of cats experimentally subjected to CO poisoning.
The pathological findings we obtained were divided into two groups. The first group represents the diffuse lesions of incomplete necrosis in the cerebral white matter, and the second represents the lesions of softening in the cerebral cortex, globus pallidus, substantia nigra and Ammon's horn and necrosis in the granular layer and partial loss of Purkinje cells in cerebellum.
In favor of the exemplified results from the experimental study on cats, these neuropathological findings enable us to assume that the former group is counted to necessitated, particular change due to CO intoxication the feature of which is comparatively similar to those of edematous necrosis in the white matter, whereas the latter occasionally demonstrated as the sequelae of severe impairment of cardiopulmonary function. Subsequently, this may also link with deficient circulation as well as hypoxaemia in various ways in the brain as a possible pathogenesis.
