Abstract
In the same 76 cases of urticaria who have been treated and observed in our Allergy Centre during the past one year and partly reported in Part 1, the results of clinical studies especially on the examinations of gastro-intestinal and hepatic function and on the routine clinical examinations are as follows:
1) It is considered that urticaria has relation to digestive disorders, because 54.2% of cases had complaints of obstipation, diarrhea or abdominal discomfort.
2) In more than half of 14 cases with chronic urticaria who received gastric juice analysis, the decrease of gastric acidity was observed (achylia in 2 cases, and hypoacidity in 6 cases). One of 3 cases, was diagnosed as gastritis by G.I. series, which revealed the prolongation of gastric emptying time and a tendency of passage acceleration of small Intestine due to hyperkinesis.
It is considered that the gastro-intestinal symptoms in cases of (urticaria have two meanings: either (1) gastrointestinopathia allergica concurrent with urticaria, or (2) gastro-intestinal symptoms as the cause of urticaria, that is, as the routh of allergens.
3) In only 2 cases with chronic urticaria, chronic hepatitis was confirmed by liver function test. By treating of chronic hepatitis the eruption due to urticaria disappeared.
4) Serum total protein was normal in most of the cases; however, A/G ratio had tendency to increase, and y-globulin fraction decreased.
5) Serum electrolyte (Na and K) was in normal level in almost all subjects, except few had slight increased or decreased level.
6) In the clinical routine examinations, the following results were obtained.
a) Hypertension was seen in 14.9 of the patients ; and in the majority of hypertensives, the increase of serum total cholesterol was noted.
b) Leucocytosis was seen in 22.5%, and eosinophilia in 22.8%.
c) Albuminuria was observed in 6.2% of the patients. Glycosuria was not proved in all subjects. Increase of urobilinogen in the urine was seen in 49.2%.
