Abstract
In 1956, Nishimura and Shibata reported that tyrosine metabolism was abnormal in patients with dermatomyositis.
Since 1963, Matsumura and Shibata have studied the tyrosine metabolism of rats given repeated loads o tyrosine.
From our biochemical and immunological experiments, a large amount of p-hydroxyphenyl pyruvic acid is excreted in the urine from rats given repeated loads of tyrosine or thyroxine.
These findings suggested that the loaded tyrosine might be convented to thyroxine, the depression of suprarenal function was observed and then a large amount of hydroxyproline might be excreted in the urine.
