Abstract
We examined the correlation between fasting blood sugar (FBS) and incidence of hyperlipidemia and or hyperacetoacetatemia in diabetic patients in general and in association with condition of the disease. Then, effect of treatment for diabetes on hyperlipidemia and hyperacetoacetatemia was observed. No blood lipid lowering drugs were administered to the patients before and during the observation period. The results were as followings.
1) There was linear positive correlation between serum cholesterol (Ch) and betalipoprotein (bL) levels and between Ch and triglyceride (Tg) levels, but no correlation was found between FBS and Ch, or between FBS and Tg levels.
2) There was no correlation between plasma acetoacetate (Ac) and FBS, Ch, Tg or bL levels.
3) At the beginning or reestablishment of treatment of diabetes, abnormally high levels of Ch were found in 54% of the cases, of Tg in 52%, of bL in 48%, of Ac in 79% of the cases, respectively.
Incidence of hyperlipidemia and hyperacetoacetatemia was independent on FBS level, sex, or retinal lesions, but hypertriglyceridemia was found less frequently in the groups of under 40 years of age, of emaciation, and hyperacetoacetatemia being less frequently in the group of obesity.
4) After the treatment for 1 to 12 month's peiod abnormal high levels of Ch, Tg, bL and Ac were improved significantly in incidence of 62%, 41%, 38%, 52% of the abnormal cases, respectively.
Kypercholesterolemia was more frequently improved in the group in which post-therapeutic FBS was maintained under 14.0mg dl, in female group, in the group of under 40 years of age, and in the group with no significant retinal lesions. Hyperacetoacetatemia was more frequently improved in female group and in the group of emaciation. Hyperbetalipoproteinemia was more frequently improved in the group of under 40 years of age, in the group of emaciation and in the group with no significant retinal lesions.
