Abstract
It goes without saying that the quality control of medical drugs in the practice of a hospital pharmacy, and the combination of powdered drugs, especially, is one of the greatest concerns for us, pharmacists.
The imcompatibility of powders was usually seen only according to change in appearance of combined powders, and chemical reaction or decomposition of each ingredient causin glowered content was mostly unknown in the past.
Now, we tried to observe, day by day, the physical change on the combinations of Vitamin K1 powder, frequently prescribed in our hospital, with various powdered a drugs and daily change of Vitamin K1 content contained in the combinations.
The present report describes the gist of the results of our experiments.
I. Change in appearance of combined powders.
According to regular method, we combined Vitamin K1 powder and thirty-two in gredients most probably expected to be mixed, respectively, and observed for the period of 1 to 18 days, shut off from sunlight, at room humidity 60% and room temperature of 18-20°C.
These combinations, more or less, became damp and changed in color, especially remarkable on combination with Hoparon, sodium bicarbonate, Hesna, Neophyline, prednisolone (1%), Adona, Aspirin, Guronsan, orotic acid, Sanaktase, magnesia, dexamethasone (0.1%), Apresoline (10%), vitamin E, Monophyline, papaverine hydrochloride (10%), Tropin, Abirol, Almi-Gel, Contol and calcium pantothenate (10%).
II. Change in content of Vitamin K1 contained.
We mixed Vitamin K1 powder with 12 of these ingredients demonstrated most remarka ble change, sodium bicarbonate, Hesna Neophyline, predonisolone, Aspirin, magnesia, dexamethasone, Guronsan, Monophyline, Tropin, Scopolia extract powder and papaverine hydrochloride. These combined powders were, respectively, measured photometrically at intervals of 1, 2 and 3 days after mixing indivisually prescribed in—lightresistant hermetic container, hermetic container and imitation Japan paper—on the cotent of Vitamin K1 contained.
We found the Vitamin K1 content of any combinations had been already reduced about by half when the change in color or appearance appeared.
From these facts, it is considered attention should be directed to this problem, change in content by combination of not only Vitamin K1 powder but also any other powdered drugs.
