Abstract
Primary cancers of the liver were examined clinically and pathologically on about 22 autopsy cases. Out of these 22 cases, 18 cases were hepatomas combining with cirrhosis of the liver in 9 cases and 4 cases were cholangiocarcinomas showing no cirrhotic changes.
Regarding to clinical symptoms of these 22 cases, 12 patients had fever and ascites was observed on 16 patients in which bloody ascites was proved in 10 cases. Jaundice also appeared on 16 patients. Abdominal pain was severe in patients who had remarkable hemorrhage and necrosis of the liver and these were no distinct relations between ab-dominal pain and weight of the liver, extension and metastasis of the tumor. Ascites was remarkable in cases which had pressure or obstruction around the porta hepatis and cirrhosis of the liver. Bloody ascites was mainly observed in cases which had liver weighed over 2, 500 grams or in cases which had very extensive tumors. Also all cases that had ascites and died within a month showed bloody ascites. Jaundice was not so remarkable in cases which pressed on porta hepatis but was remarkable in cases which had extensive tumor invasion in the liver. In the cases that showed jaundice, depositions of bile pigments were eminently seen in liver cells and the aspects which were suggestion of the secretion of bile pigments by tumor cells were observed partly. High fevE r appeared in cases which had marked infiltration of leukocytes combined with infection, hemorrhage and necrosis of the liver. Antibiotics were not effective in the most of caves which had slight fever under 38°C and had little complication of infection.
