Abstract
As a method to make greater improvement for radiation therapy it should be investigated upon the combined treatment with some antitumor agents in different fields.
An attempt was made to determine whether lymph node cells from C3H/He mice are capable to produce cellular antitumor activity against spontaneous mammary carcinoma of imbred mice.
Mouse abdominal macrophages were sensitized by cultivation with the supernatant fluid which obtained from culture medium of mouse mammary carcinoma 16 hours after irradiation, and lymphh node cells were sensitized by mix-cultivation with the sensitizing macrophages.
Sensitized lymph node cells inhibited in vitro multiplication of target tumor cells, and also in vivo growth of tumor which implanted into thigh muscle. Tumor growth of mice treated with irradiation and sensitized lymph node cells was inhibited remarkably, and 40 of them regressed tumor disapparently.
