Abstract
Although the early diagnosis of acute myocardial infarction (A. M. I.) is very important for acute coronary care, the E. K. G. interpretation may be sometimes difficult because of the pre-existing abnormalities of the E. K. G. such as W. P. W. syndrome, bundle branch block etc. In such cases, the determination of serum enzyme activities plays very important role in the early diagnosis.
Four serum enzyme activities (S-C. P. K., S-G. O. T., S-L. D. H., S-α-H. B. D. H.) were determined by the U. V. method (wave length 340 nm). The precision of the determined values by this method are as follows:
S-G. O. T. 30.8×2.0mU/ml C. V. 6.6%
S-L. D. H. 128×8.5mU/ml C. V. 6.6%
5-α-H. B. D. H. 189×6.6mU/ml C. V. 3.5%
S-C. P. K. 116×1.4mU/ml C. V. 1.2%
The above precision is satisfactory enough for our clinical purpose.
Studied patients were divided into five groups;the groups of controls (10 cases), angina pectoris of effort (5 cases), angina pectoris at rest (5 cases) and A, M, I, (10 cases) The serum enzyme activities of each of the groups were determined with the following results:
No statistical difference of the serum enzyme activities was obtained between the groups of control and either angina pect. of effort or angina pest, at rest. But significant differences of each of the four enzyme activities was obtained between the control and A. M. I. groups. In A. M. I. groups, S-C. P. K., and S-G. O. T. levels showed rapid elevation and rapid falling;these two enzyme values returned to normal on the 7th day of the attack. On the contrary, S-L. D. H. and S-α-H. B. D. H. levels showed slow elevation and slow falling;these two enzyme values still remained high even on the 7th day of the attack.
As the above results coincide with the data formerly reported by other investigators and the time required for the enzyme determination is short, the U. V. method can be useful method for the early diagnosis of A. M. I.
