Abstract
In order to establish high-risk pregnancy for neonatal hyperbilirubinemia, 8, 548 infants delivered at the Fukuyama National Hospital were studied. As a result, fetomaternal Rho blood group incompatibility, A- or B-blood group infant from O-blood group mother, infant from toxemic mother, premature rupture of the membrane, dystocia, vacuum extraction, neonatal asphyxia, neonatal respiratory distress, cephalohematoma, hypothermia, abnormal reduction in neonatal bodyweight, pseudomelena, neonatal hemoconcentration were estimated to be high-risk for neonatal hyperbilirubinemia. Administration of anti-Rho immunoglobulin, qualitative manage-ment of pregnancy toxemia, delivery of newborn at the optimal gestational week, prevention of low birth weight, fluid therapy for low birth weight and distress infant, prenatal enzyme induction for high-risk pregnancy, light therapy and so on were also thought to be effective for prevention of neonatal hyperbilirubinemia. Frequency of neonatal hyperbilirubinemia could be reduced to 1%
