Abstract
Our serious endoscopic examinations followed-up for five years after healing of gastric ulcer revealed that rate of the recurrence was high and estimated 80%.
In addition, we had an impression that the recurrence occurred toward some directions which might be determined by some regulating factors. In order to make this possible factor clear a histopathological approach was attempted on specimens obtained from resected stomachs and the results were as follows.
Ulcers of the corpus were generally accompanied with the more intensive fibrotic hyper-plasia at the oral side than the anal side. Decrease in the diameter of the vessels in the neighborhood of the initial ulcer was more marked at the oral side of ulcers in the antrum, angle and the lower potion of the corpus, while more detectable at the anal side of ulcers in the middle and upper corpus. It is probable from the above-mentioned results that submucosal fibrotic hyperplasia and decrease of the size of the vessels are significant regulating factors.
On the other hand, a group of findings found around healing or scarred ulcers, i.e., mucosal atrophy, abnormal redness, discoloration and narrowings of the folds similar to IIc lesion, was named the gazonal gastritis, which is considered to be a sign of a large possibility of recurrence.
