Abstract
Increases in the activities of cerebrospinal fluid enzymes (e. g. GOT, GPT, LDH, CPK and etc.) are frequently noted in various states of CNS disorders, but those mechanisms are complicated.
Enzymatic activities and gas analyses in CSF of a 24-years-old male after poisoning with Ethinamate taken for suicidal purpose were investigated. GOT, GPT and LDH activities in CSF were not so elevated. On the contrary, the activity of CSF-CPK was much increased to 87 units and pH and HCO-3 in CSF were decreased to 7.233 and 9.9 mEq per litter respectively and CSF oxygen tension diminished slightly.
In our investigation, we observe that in almost all cases of cerebrovascular insufficiency the CP'K activity tends to be greater than in the control and normal CPK cases in CVI scarecely consist in the region of the low levels in both pH and HCO-3.
Therefore we presume that the metabolic disorders such as hypoxia or acidosis might be one of factors by which the level of CPK in CSF might be elevated.
