Abstract
Cyclophosphamide is one of antitumor agents widely used in the treatment of various types of tumor. This drug has been marketed in tablet form for oral administration in Japan.
Occasionally, doctors would express a need of administration of the drug orally in powder form. Cyclophosphamide was triturated with lactose, corn starch and potato starch, and stability of three triturations was studied. Furthermore, stability of Cyclophosphamide trituration with lactose packaged by Glassine-Poly-laminated paper and its compatibility with other 31 preparations were tested.
The present results were suggested;
1) Three triturations were stable if they were stored in refrigerator or at room temperature.
2) Cyclophosphamide trituration with lactose was unstable in ovens at 37°C.
3) When Cyclophosphamide trituration with lactose will be dispensed, pharmasists must advice patients that it will be stored in airy low temperature place (below 30°C).
