Abstract
Very inveterate schizophrenic symptoms of hyperkinesia, impulsive-manneristic behavior and severe sleep diturbance which had been incorrigible by neuroleptics and/or lithium bicarbonate were successfully treated with help of GABA (γ-amino butyric acid) in two patients. After several relapses, one male patient stayed hospital for twenty-seven years in dilapidated state with recurrent psychomotoric excitement. The other male patient had had schizophrenia at thirteen years old and showed very regressive state for the last four years.
When 1.5g or 3g of GABA was given per os in combination with neuroleptics and lithium bicarbonate, the psychomotoric excitement and sleep disturbance disappeared a few days later. Whereas only GABA was withdrawn from the prescription, the psychomotoric excitement and sleep disturbance reappeared.
GABA can not penetrate into the brain because of unable to cross the blood-brain barrier. So GABA should work on the peripheral tissue, especially neuro-muscular system from which impulse originate and is sent to the brain. Impulse flow pattern plays a very important roll of forming stimulus-response level, i.e. threshold in the brain. Dramatically altered impulse flow pattern from the musculature under GABA may be forced to reset the threshold in the brain for the psychomotoric expression.
