Abstract
Steroid hormones and immunosuppresants have generally been used in treating patients with collagen diseases and the significance of immunotherapy in such diseases has been recently reported in SLE nephropathy. It is said that abnormality of cellular immunity is involved and that the possible effect of immunotherapy might be expected in SLE nephropathy.
In this study, we administerated PS-K (Krestin) to 5 patients with SLE nephropathy who has relapsed 5-8 times. All of these patients have been treated with steroid hormones and immunosuppresants.
Doses administered was 3 grams PS-K per day combined with steroid for3-8 months, and observation period was 6-22 months.
Two out of 5 patients, relapse or recurrence was stopped in observation period and urinary protein excretion was also decreased.
This type of immunotherapy might be promising in SLE nephropathy in the future.
