Abstract
Monoclonal gammopathies without evidence of multiple myelom, primary macroglobinuria (Waldenström) or other related diseases is defined benign monoclonal gammopathies (BMG).
BMG is usually classified into primary and secondary types. Many excellent reviews on BMG have been published, but reviews on secondary BMG are few. Secondary BMG have been occasionally found in patients with lymphoprolif erative diseases, cancer, infectious diseases, autoimmune diseases and chronic liver diseases. But the significance of secondary BMG is poorly understood and there is possibility that fortuitous coexistence with primary diseases and primary BMG are sometimes considered secondary BMG. Discussing these problems, clinical significance of secondary BMG is reviewed. Careful follow-up of relationship between M-component and clinical course is necessary in the diagnosis of secondary BMG.
