Abstract
Fifty cases of primary osteogenic sarcoma have been treated in the Department of Orthopedics during 28 years since the opening of Nagoya National Hospital in September 1954 till August 1982. The results of treatment were assessed, discussed and reported.
Among 50 cases, there were 24 cases of osteosarcoma, 6 chondrosarcoma (2 of those 6 had multiple exostosis and became malignant), 6 fibrosarcoma, 2 reticulosarcoma, 4 Ewing's sarcoma, 2 malignant giant cell tumor, 1 mesenchymal malignant tumor, 2 chordoma, 1 malignant fibrous histiocytoma, and 2 periosteal osteosarcoma.
Twenty-five cases (50%) ranged in age from 10 to 19 years old, and there were 35 males and 15 females.
Radiotherapy, chemotherapy and/or surgery were used for therapeutic means. High dose M. T. X, therapy has been used recently.
In 75% of osteosarcoma and 65.3% of tumor other than osteosarcomas, the sites of tumor were the femur, tibia and fibula.
Of these various tumors, osteosarcoma, Ewing's sarcoma and reticulum cell sarcoma had bad prognosis, as reported by others.
In the relation between the site of onset and prognosis, the onset around the knee joint distal to the half femur and proximal to the half tibia showed a tendency to better prognosis than the onset in other sites. Further, concerning the preoperative period and prognosis, cases of longer preoperative period generally showed tendencies to better prognosis, suggesting the relation with the malignancy of tumor tissue.
Concerning the combination of chemotherapy with other treatments, no clear conclusion has been obtained about the effects, since the numbers of cases were few for each treatment.
