Abstract
Since April 1973, we have applied total body irradiation (TBI) for bone marrow trans-plantation (BMT) in leukemia which became resistant to conventional therapy. Prior to BMT, patients were conditioned for engraftment with cyclophosphamide, followed by 10 Gy TBI with 6 MV or 10 MV Linac X-ray. Bone marrow cells from donor were infused intravenously one day after TBI.
The longest survival time was 57 months after BMT and this patient was still alive with complete remission at the time of writing this paper.
The treatment was tolerated reasonably well, with acceptable side effect of irradation and graft versus host reaction.
