Abstract
Lymphnodes have the architecture of network consisted of reticulum cells and reticulum fibres populated by lymphocytes and are divided into cortex and medulla. In the outer layer of the cortex there ane follicles consisted of B-cells and the inner layer, paracortical area, are mostly consisted of T-cells. Infection, inflammation and malignancy alter such architecture of lymphnodes and distribution of B-cells and T-cells as well. Alteration of B-cell clone causes changes of immunoglobulin synthesis. Lymphadenopathy associated with dysgammaglobulinemia is not unusual and changes of immunoglobulin are important in the diagnosis and prognosis of lymphadenopathy.
