Abstract
A series of ointment was prepared. Hydrophilic macrogol, hydrophobic vaseline and witepsol were used as base materials. Each ointment contained insulin (eight units per gram weight). In order to study in vivo release of insulin from each ointment, blood glucose was measured after application of the materials on the rat abdominal muscles.
The initial fall of the blood glucose caused by the insulin-witepsol ointment was almost as same as that caused by the insulin-saline solution. However, the duration of the hypo-glycemic period of the insulin-witepsol ointment was shorter than that of insulin-saline solution. After the application of the insulin-vaseline ointment, the blood glucose de-creased more gradually and the hypoglycemic state continued for a longer period.
Insulin-macrogol ointment, which was made completely of commercially available mate-rials, has a least blood lowering effect and a shortest hypoglycemic period. Clinically, Insulin-macrogol ointment was applied on a skin ulcer in diabetics, and no side effect was observed.
