Abstract
Four cases of multiple primary carcinoma of the esophagus associated with dysplasia were found among seven patients with squamous cell carcinoma of the hypopharynx who received total esophagectomy with pharyngolaryngectomy at the Shikoku National Cancer Center Hospital. Two cases of minute carcinoma were observed in these cases. One of them appeared too small to detect clinically despite the application of esophagoscopy with the Lugol's solution spraying emthod. Since all four patients had a long history of smoking and drinking, smoking and drinking seemed to have very much to do with the carcinogenesis. These findings suggest that total esophagectomy is applicable to patients with hypopharyngeal cancer, particularly to those who continue to drink and smoke regularly.
