Abstract
Chromosome analysis using the G-banding method was performed on cultured lymphocytes in 100 married couples with history of spontaneous abortions more than 2 times. The results of this survey showed that 8 wives and 2 husbands of ten couples (10%) had congenital chromosome abnormalities; a balanced type of reciprocal translocation between two chromosomes, or a centric fusion type of translocation between two acrocentrics. As the incidence of translocation carriers of these types in newborn population in Japan was estimated at 0.146%, it was revealed from the present study that translocation carriers were markedly concentrated in couples with spontaneous abortions 54.8 times in wife's and 13.7 times in husband's population than the general population. As a practically meaningful suggestion, the correlation of chromosome abnormalities with the prior reproductive history of couples has been established from the analysis of the published data.
