Abstract
A 66-year-old male came to the hospital because of general fatigue and loss of appetite. Laboratory examination showed that serum protein 12.5g/dl, albumin 2.53g/dl, α1-globulin 0.13g/dl, α2-globulin 0.32g/dl, β+γ-globulin 9.49g/dl, Immunoglobulin; IgG 8696mg/dl, IgA 130mg/dl, IgM 216mg/dl, IgE 380U/ml and serum electrolytes; Ca 9.0mg/dl, P 11.9mg/dl. Roentogenological studies revealed that calcification of ligamentum nuchae and soft tissue around cubital joints. Plasmacytosis was seen in bone marrow (11.6%) liver and lymphnode tissues. During about one month, Alkeran 2mg/day and Prednisolone 10mg/day were administered orally with transient effect. IgG gradually decreased to the level of 3000mg/dl and serum Ca and P levels also became normal after successive twelve months. Cause of calcification of various tissues and hyperphosphatemia were suspected to increased binding of calcium to hypergammaglobulin and subsequent lowering of calcium ion concentration.
By reviewing IgG producing cells of peripheral lymphocytes in vitro, it was proved that activity of helper T-lymphocytes were highly activated and that of suppressor T-lymphocytes were reversely dropped in this patient.
