Abstract
We often see a hepatomegaly or an abnormal liver function test during the clinical course of patients with leukemia. In these cases, it is very difficult for us to diagnose exactly what the liver disease is like. So, histological findings of the biopsied specimen from the liver become diagnostically most important. We report here two cases of liver disease, liver cirrhosis and liver injury complicating with chronic myelocytic leukemia (CML), which were based on a histological evidence.
Case 1 was 56-year-old male, who was admitted due to chest pain caused by an attack of angina pectoris. He was diagnosed as CML for the first time upon this admission. Peritoneoscopy showed cirrhotic liver with splenomegaly and histology disclosed pseudolobule formation consistent with liver cirrhosis without an invasion of CML cells.
Case 2 was 61-year-old male, who was diagnosed as CML in October 1985. He had persistent hepatomegaly and biopsied liver tissue revealed leukemic cell infiltration with portal fibrosis.
The cases of liver disease, especially liver cirrhosis associated with CML with a histological evidence of the liver damage have been very rarely reported till now.
