Abstract
We studied the effects of Marzulene-S, Glumin, Maalox, and Gentiana+Distase+Sodium Bicarbonate (1:2:6) mixture on development of acute gastric lesions induced by aspirin or water-immersion stress in rats. All drugs except Marzulene-S given p. o. for 1 week dose-dependently inhibited the development of gastric lesions induced by aspirin (300mg/kg, p. o. pH 2.0). However, all drugs inhibited the development of gastric lesions when they were given 30min, before aspirin administration or water-immersion stress. The rats were given the drugs for 1 week and they were fasten for 30 hours. In this experiment, the pH of rat's gastric mucosa was changed from 5.0 to 2.0. This acidification of pH was prevented by PGE1 100μg/kg p. o., which was rapidly administered. The absorption of aspirin was not significantly influenced by these drugs.
These results suggest that these drugs have protective effect on gastric mucosa, but that acid rebound develops after discontinuing administration of the drugs, which is prevented by PGE1.
