Abstract
The clinical features of pituitary insufficiency are related to the lack of individual pituitary hormones and their specific target gland secretion. We experienced two cases of hypopituitarism with no definite symptoms but consciousness disturbance by chronic hypoglycemia. One case was 44 year old male and the other was 67 year old female. There were not enough signs and symptoms suggesting hypogonadism and hypothyroidism. The endocrinological examinations were performed because of the documentation of hypoglycemia and the reversibility of the symptoms upon administration of glucose, and a diagnosis of idiopathic hypopituitarism was made.
In reviewing 1058 cases of hypopituitarism in Japan, the symptoms relating to a deficiency of gonadotropin and/or thyrotropin were more common than those of hypoglycemia (only 13.4%).
It was of interest in the present case that there was isolated symptom of ACTH deficiency and that symptoms of other pituitary hormone deficiency were little.
