Abstract
A 63 year old male with an advanced gastric cancer (Borrmann type 2) was treated by endoscopic direct injection of OK-432. The case was inoperable due to respiratory dysfunction caused by old pulmonary tuberculosis. OK-432 (10 KE) was directly injected into thet umor endoscopically every one or two weeks for the duration of six months. Although cancer tumor and crater disappeared and no cancer cells could be detected in biopsy specimen, endoscopic ultrasonography revealed residual submucosal cancer. The same protocol was continued for another six months and the submucosal cancer subsided. Additional endoscopic administration of OK-432 was continued for another one year. We discontinued the treatment after 75 times of direct injection (total dose of 750 KE). It is already more than three years after the initiation of the treatment, the patient is alive without no evidence of recurrence or metastasis.
