Abstract
Serum apoprotein A-1 and A-2 levels were determined by TIA (Turbidometric Immu-noassay) in patients with various liver diseases. Significant decreases in apoprotein A-1 and A-2 levels were obserbed in such patients. The decreases in A-2 levels were more prominent than the decreases in A-1 in chronic liver diseases, but not in acute hepatitis. The A-1/A-2 ratio increased significantly in chronic liver diseases according to the degree of liver damage and correlated significantly with serum choline-esterase activity, suggesting that the A-1/A-2 ratio was valuable as a marker of degree of liver damage in chronic liver diseases. Further study including the patients with fulminant hepatitis other than severe chronic liver diseases is needed to evaluate the value of A-1/A-2 ratio as a prognostic marker as well as a marker of degree of liver damage in severe liver diseases.
