REGIONAL CEREBRAL BLOOD FLOW USING ¹³³XENON INTRA-VENOUS TECHNIQUE

(2) —EVALUATION OF REGIONAL CEREBRAL BLOOD FLOW IN PATIENTS WITII CEREBROVASCULAR ISCHEMIC DISEASE—

Abstract

Using the ¹³³Xenon venous method, we have studied the regional cerebral blood flow (rCBF) in 947 patients with cerebrovascular ischemic disease. In 116 stroke or TIA patients with internal carotid artery occlusion or severe stenosis, their rCBF revealed 48.9ml/100g/min on average in the group of one side occlusion, 46.7ml/100g/min in the group of one side occlusion and the other side severe stenosis and 47.0ml/100g/min in the group of both sides occlusion. These values reduced approximately 12%, 16% and 15% of the rCBF in healthy volunteers of same age, respectively.
In 28 patients with moya moya disease, their rCBF tended to be higher in younger N cases and lower with advantaed age. In the majority of the cases, their rCBF was age-dependent with 20-25ml/100g/min below the curve of age-matched rCBF of healthy volunteers. The reduction of rCBF was observed in 69 (48.3%) of 143 cases clinically, diagnosed as small vessel disease, in 58 (41.4%) of 140 cases with vertebrobasilar insufficiency and in 23 (44.2%) of 52 cases with syncopal attack compared with the rCBF of healthy volunteers.