Abstract
Prostate specific antigen (PA), gamma seminoprotein (γ-Sm) and prostatic acid phosphatase (PAP) have been evaluated in 98 patients with prostatic cancer, 189 with benign prostatic hyperplasia, 7 with acute prostatitis and 32 with other urological diseases.
Normal upper value, or 2 SD of 197 healthy males was 2.8ng/ml for PA. However, because of the prevalence of false positive with this value, the cut-off value for PA was set at 7.4ng/ml, for γ-Sm 4ng/ml and for PAP 1ng/ml. The mean values of PA, γ-Sm and PAP were significantly high in the prostatic cancer. Of the 23 patients with untreated prostatic cancer, 82.6%, 60.8% and 56.5%, respectively, were detectable using a single assay. serum PA levels in 23 patients with untreated prostatic cancer were higher in advanced stages and in poorly differenciated adenocarcinoma. This study shows that PA is more reliable than γ-Sm and PAP indetecting and staging of the prostatic cancer.
