CLINICAL TRIAL OF PROPHYLACTIC TREATMENT WITH SULFAMETHOXAZOLE-TRIMETHOPRIM TO THE FEBRILE EPISODES IN SEVERELY HANDICAPPED CHILDREN

Abstract

We assessed the efficacy of oral sulfamethoxazole-trimethoprim (ST) in the prevention of bacterial infection in four severely handicapped children, who were admitted to the Suzuka Byoin National Sanatorium. The frequency and duration of the febrile episodes were decreased by the administration of ST (62.5mg/kg body weight) for 6-12 months judging from the decrease of the markers of infection. These data suggested that the prophylactic treatment with ST might be one of the beneficial treatments to improve the quality of life in severely handicapped children.