Abstract
A case of disopyramide-induced hypoglycemia is reported. A 64-year-old male was admitted to our hospital with complaints of dyspnea, heart failure, sweating and discomfort in the early mornings. Fasting blood sugar (FBS) demonstrated hypoglycemia (31mg/dl). Immunoreactive insulin (IRI) was low (<3μU/ml) in the state of hypoglycemia. When oral administration of 300mg/day disopyramide was stopped, complaints of sweating and discomfort in the early morning disappeared and FBS was normalized. Rechallenge with disopyramide showed hypoglycemia again (58mg/dl). But when disopyramide was stopped, FBS was normalized again. These results suggested that the mechanism of disopyramide-induced hypoglycemia in the morning might have not related to the level of plasma IRI level and rather related to the general condions in this case.
