Abstract
Using 123 gynecology laparotomy patients, 53 from preliminary experiment and 70 from multi-clinical experiment, who still were deeply sedated at the end of anesthesia, we studied the effect of flumazenil from anesthesia supplemented by benzodiazepine and pentazocine. The patients were intravenously inducted for anesthesia with one of the benzodiazepines, either diazepam 0.3mg/kg, flunitrazepam 0.03mg/kg or midazolam 0.3mg/kg and pentazocine 1mg/kg. The anesthesia was maintained with nitrous oxide, a muscle relaxant and additional pentazocine and benzodiazepine when needed. At the end of each operation, f lumazenil 0.3mg was administered intravenously. If after 4 minutes its effect was insufficient, additional flumazenil 0.1mg was administered. Results: 1 minute after the administration of flumazenil, 83.3% (preliminary), 90.0% (multi-clinical) of the patients in the diazepam group, 100.0% (preliminary), 70.8% (multi-clinical) in the flunitrazepam group and 87.5% (preliminary), 76.9% (multi-clinical) in the midazolam group were completely conscious. The effects of restoring cognizance and orientation were excellent but had a slight effect on anterograde amnesia. No side effects were encountered.
