Abstract
Plasma concentration of lidocaine and α1-acid glycoprotein (AAG) in 10 patients with acute myocardial infarction were analyzed by FPIA (fluoresence polarization immunoassay) and SRID (single radial immunodiffusion) method during lidocaine infusion continuously. Concentrations of lidocaine and AAG tended to rise in all, leading to failure of lidocaine clearance and binding of the drug in plasma. The lidocaine clearance data were analyzed by Fisher's t-test and the significance of the difference was found 3-h (0.553ml/hr/kg) between 48-h (0.356ml/hr/kg) at the 0.1 significance level. AAG concentration was correlated with lidocaine concentration at the 0.796 coefficient of correlation. The rate of rising AAG concentration in 5 patients with heart failure were greater than others, so there was significance difference between these two modes of slopes in regression equation at the 0.05 significance level by t-test analysis. If lidocaine clearance depended on the duration of infusion and AAG, a Bayesian estimation program was defined by the rule: Cp=D/(α·weight-β·AAG-γ·t). In this individual analysis, establishment of lidocaine infusion dosage was based on average rules: D=Cp·(0.439 wt-0184 T-0.0294 AAG) in cases of heart failure, D=Cp·(0.935 wt-0.445 T-0214 AAG) in cases of others (non-heart failure).