Abstract
Various immune complex diseases responding to massive dose of γ-globulin have recently been reported, but the mechanism of that has not yet been clarified. In the present study of the, effect of γ-globulin on blood coagulation time in vitro using plasma of a non-hemophilic patient with an aquired inhibitor against Factor VIII, the authours found that prolonged APTT improved well to normal level when γ-globulin was mixed. This suggests that the mechanism of massive γ-globulin is to make free antibodies against Factor VIII from antigen-antibody complex.
