Japanese Journal of National Medical Services
Online ISSN : 1884-8729
Print ISSN : 0021-1699
ISSN-L : 0021-1699
IN VITRO ANTIMYCOBACTERIAL ACTIVITY OF TOSUFLOXACIN
Shin KAWAHARA, Atsuhiko TADA, Makoto TAKEUCHI, Ken KAMISAKA, Chiharu OKADA, Yasuo MISHIMA, Ryo SODA, Kiyoshi TAKAHASHI, Masayoshi KIBATA, Hitoshi NAGARE, Yuko KITANO
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Keywords: tosufloxacin, in vitro antimycobacterial activity, blood concentration
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1993 Volume 47 Issue 12 Pages 942-946

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Abstract
In vitro antimycobacterial activity and blood concentration after administration of tosufloxacin (TFLX) were studied to evaluate it's therapeutic potential against mycobacterial infections. In this study, the actual count method was adopted to measure the minimal inhibitory concentration (MIC) using Ogawa egg medium.
In vitro antimycobacterial activity of TFLX was much lower than that of ofloxacin. It was supposed that TFLX has a weak therapeutic potential against mycobacterial infections except for mycobacterium fortuitum or mycobacterium scrofulaceum infection considering blood concentration of this drug.
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