CLINICAL STUDY ON THE CASES OF ULCERATIVE COLITIS COMPLICATED WITH COLORECTAL CANCERS

—COMPARISON WITH ULCERATIVE COLITIS COMPLICATED WITH COLORECTAL ADENOMAS—

Abstract

We experienced an autopsy of multiple colorectal cancers associated with ulcerative colitis, 20 years having passed since the onset of UC. Analysing 184 cases with color-ectal adenomas or carcinomas associated with UC reported in Japan from 1962 to 1991, we discussed about the following four points. Those were 1) the age at the diagnosis of adenomas or carcinomas, 2) the duration of UC, 3) the extent of the lesions in UC and the distribution of the adenomas or carcinomas, and 4) the frequency of dysplasia. ?From these points of view, colorectal carcinomas associated with UC had those char-acters. 1) The diagnosis of carcinoma was performed at younger age than that of other colorectal carcinomas or adenomas. 2) The duration of UC was long. 3) Total colitis was the most common type. 4) Dysplasia was seen frequently. And these points showed the possibility of the inflammation of the colonic mucosa having much connection with the onset of cancer. The surveillance system to follow the UC cases is requested.