Abstract
Recently, local chemotherapy has been used as an useful treatment for carcinoma of the uterine cervix. We prepared vaginal and endocervical suppository for clinical use using cisplatin (CDDP) powder made from commercially-available CDDP solution by vacuum distillation method, and practiced local chemotherapy with CDDP suppository in patients with carcinoma of the uterine cervix. As to the pharmaceutical properties of each suppository, weight variation test showed 1316.3±20.1 mg in vaginal suppository and 236.1±1.9 mg in endocervical suppository, and content test by high performance liquid chromatography demonstrated 9.67±0.39 mg in vaginal suppository and 10.92±0.18 mg in endocervical suppository, respectively. Coefficient of variation was good enough in each test.
Investigation of content uniformity in three divied parts of vaginal suppository suggested the importance of controlling its good quality in preparation. Histological response of the tumor showed Grade 0-IIa in the squamous cell carcinoma of the uterine cervix. No major side effects were seen in this study, but redness or erosin of vaginal mucosa was the only side effect in most patients after the therapy.
