Abstract
It is necessary to consider about the effects of the cerebral blood flow (CBF) when the drugs were administered to the patients with cerebral vascular diseases. Cerebaral vasodilator will be expected to increase the cerebral blood flow. Some drugs that participate in an improvement of the cerebral metabolism were also expected to cause indirect increase of the cerebral blood flow. On the other hand, the antihypertensive drugs were desired not to produce adverse effects to the cerebral blood flow when blood pressure was reduced during the course. The present study was performed to evaluate the effects of the drugs administered to the patients with cerebral vascular diseases from a viewpoint of CBF measurement. Regional CBF (rCBF) measurements were obtained using the 133Xe inhalation method. Mean hemispheric rCBF values (mCBF) were calcculated in both the affected and non-affected hemispheres. According to the 9 rCBF values of the affected side at the measurement before drug administration, CBF values were devided to 3 flow levels. Each parts were named as low, middle and high flow region. Nilvadipine has cerebral vasodilating action. When administered orally over 8 weeks, Nilvadipine showed significant increase of the mCBF in the affected hemisphere. An increase of the rCBF is marked at the low flow region. These results are considered to be beneficial as cerebral vasodilatator. The same results were obtained when Bifemerane administered orally. Bifemerane also seemed to have the desirable effects on CBF. Nipradilol (the antihypertensive drug)has no effects on CBF in hypertensive patients with cerebral vascular diseases.
