Abstract
A patient with Crow-Fukase syndrome or multiple myeloma shows monoclonal gammopathy. We detected IgA (λ)-monoclonal gammopathy in daughter with Crow-Fukase syndrome and in father with multiple myeloma.Case 1 was a 44-year-old foster-daughter, She was diagnosed as having Crow-Fukase syndrome as evidenced by monoclonal gammopathy, pigmentation, neuropathy, hepato-splenomegaly, pleural effusion, ascites and pericardial effusion in 1992. Case 2 was a 74-year-old foster-father. Abnormal plasma cells (35%) in bone marrow, and abnormal lesions by bone scintigram and bone Xray were demonstrated in 1993. He was diagnosed as having multiple myeloma. Her and his monoclonal gammaglobulins were obtained from both of these two cases IgA (λ).
As simultaneous onset and the same pattern of monoclonal gammopathy in these patients, some environmental factor may be the trigger of both diseases.
