Abstract
Serum drug concentration were measured by the HPLC method in 2 cases of acute intoxication.
Case 1: 63 years old female was admitted with coma about 17 hours after ingestion of an estimated dose of 3000 mg levomepromazine. After admission the patient had a cardiac arrest and serum levomepromazine level was 2018 ng/ml. After successful resuscitation, direct hemoperfusion (DHP) was tried on. Though after DHP serum drug level was 35 ng/ml, clinical condition did not change.
Case 2: 58 years old female was admitted with coma about 8 hours after ingestion of an estimated dose of 1000 mg thioridazine. Serum thioridazine level was 1895 ng/ml in admission. After 35 hours and 60 hours serum drug level was 428 ng/ml and 427 ng/ml. The elimination curve was similar to that of 2 compartment model.
