Abstract
Recently, pulmonary lymphomatoid granulomatosis (PLG) has been regarded as a lymphoproli-ferative disorder, and one third of it involves skin. We report histological features of a skin lesion which appeared in a course of PLG. A 41-year-old male had been suffering from pneumonia-like symptoms, and while the treatment with antibiotics has been performed, four nodular skin lesions were recognized on the lower extremities in 15 months. Histopathological examination of one of these skin lesions revealed subcutaneous granulomas with marked infiltration of perivascular lymphoid cells, plasma cells and histiocytes. Fibrosis with Langhans type giant cells was also seen. No patho-genic agent was demonstrated and monoclonality was not evident. Histological findings of the pul-monary lesion which was resected in 27 months were almost the same as those of skin lesion, show-ing perivascular cell infiltration without evidences of monoclonality. EB virus antigen was not de-tected. Conventional CHOP therapy for malignant lymphoma was ineffective. From the results ob-tained here, skin lesion was thought to be an involvement of PLG, which was suggestive of lympho-prolif erative disorder.
