Abstract
Recent biological studies have been progressing for analysis of cyology of leukemic cells, in childhood acute lymphoblastic leukemia (ALL). Immunologic and genetic analysis of ALL have contributed to more rational classification, relating to clinical features and prognositic factors.
Theses analysis have identified subgroups with poor prognosis. Suitable therapeutic regimens for the subgroups have been sucessing in long survival rate of the patients. The therapy consist of remmision induction therapy, central nervous system leukemia prophilaxis, consolidation and maintenance. The use of more intensive induction and consolidation therapy has improved the survival rates, especially for the patients with high risk factors. The recent studies in therapeutic regiments for childhood ALL reveales 60-80% of long term survival. As increasing number of long term survivors, it becomes important problems of late complications related to the disease or its treatmens. Devices of therapy with less toxic not only during theapy but also after off therapy, and more cureable therapies are expected.
