Abstract
We report a 57-year-old male who developed liver dysfunction while on the treatment with oxatomide, orally anti-allergic agent. He was admitted to our hospital because of nausea and jaundice after 35-day-treatment of oxatomide. Laboratory findings showed liver dysfunction with intra hepatic cholestasis (total bilirubin 7.44mg/dl, direct bilirubin 6.71mg/dl, GOT 163, GPT 232, Alp 1502, r-GTP 232). CT and ultrasonic examination did not reveal any abnormality without hepatomegaly. antibodes to hepatitis virus A, B, C and HB virus antigen were negative. Leukocytosis and eosinophilia were notable. Diagnosis of drug induced liver dysfunction was given. Oxatomide is an anti-histamine drug that inhibit both the release and the effects of chemical mediators. It has been considered to be a safe and effective drug for patients with various kinds of allergies. However it would seem appropriate that pre scribers bear in mind the possibility of this drug may induce liver dysfunction in certain patients.
