Abstract
We evaluated the concentration of soluble E-selectin (sE-selectin), which is a marker of endo-thelial damage, in patients with non-insulin-dependent diabetes mellitus (NIDDM). SE-selectin was measured in 40 diabetic patients and 32 healthy subjects. Increased sE-selectin concentrations were found in the patients with NIDDM compared to the control subjects (p<0.01). The concentration of plasma sE-selectin was positively correlated with the level of plasma glycated haemoglobin (r=0.46, p<0.01).
These results suggest that the concentration of sE-selectin may be related to blood glucose control, and that the grade of DM control is closely related with vascular endothelial damage in patients with DM.
