Abstract
While generic drugs are widely utilized in USA and European countries, they have not accepted as potential alternatives to original drugs in Japan. No appreciable differences in therapeutic efficacy should exist between generic drugs and their corresponding originals as far as their bioequivalence is assured by legitimate bioequivalence studies. In USA available lists of generic drugs are provided by FDA via printed media (i. e., Orange Book) as well as via electronic media (FDA web site). Encouragement of generic prescription should be afforded through the educational campaign of clinical pharmacology and concept of bioequivalence of therapeutic drugs.